Clinical Care

Cambridge Hopkins
RLS Questionnaire

Self Administered RLS
Rating Scale (sIRS)

Clinical practice Guidelines

01

Garcia-Borreguero D, Kohnen R, Silber MH, Winkelman JW, Earley CJ, Högl B, Manconi M, Montplaisir J, Inoue Y, Allen RP. The long-term treatment of restless legs syndrome/Willis-Ekbom disease: evidence-based guidelines and clinical consensus best practice guidance: a report from the International Restless Legs Syndrome Study Group. Sleep Med. 2013 Jul;14(7):675-84. doi: 10.1016/j.sleep.2013.05.016. PMID: 23859128.

02

Allen RP, Picchietti DL, Garcia-Borreguero D, Ondo WG, Walters AS, Winkelman JW, Zucconi M, Ferri R, Trenkwalder C, Lee HB; International Restless Legs Syndrome Study Group. Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria–history, rationale, description, and significance. Sleep Med. 2014 Aug;15(8):860-73. doi: 10.1016/j.sleep.2014.03.025. Epub 2014 May 17. PMID: 25023924.

03

Allen RP, Picchietti DL, Auerbach M, Cho YW, Connor JR, Earley CJ, Garcia-Borreguero D, Kotagal S, Manconi M, Ondo W, Ulfberg J, Winkelman JW; International Restless Legs Syndrome Study Group (IRLSSG). Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children: an IRLSSG task force report. Sleep Med. 2018 Jan;41:27-44. doi: 10.1016/j.sleep.2017.11.1126. Epub 2017 Nov 24. PMID: 29425576.

04

https://doi.org/10.1016/j.mayocp.2020.12.026 Mayo Clinic Proceedings 2021

05

Salminen AV, Clemens S, García-Borreguero D, Ghorayeb I, Li Y, Manconi M, Ondo W, Rye D, Siegel JM, Silvani A, Winkelman JW, Allen RP, Ferré S; International Restless Legs Syndrome Study Group (IRLSSG). Consensus guidelines on the construct validity of rodent models of restless legs syndrome. Dis Model Mech. 2022 Aug 1;15(8):dmm049615. doi: 10.1242/dmm.049615. Epub 2022 Aug 10. PMID: 35946581; PMCID: PMC9393041.

06

Garcia-Borreguero D, Silber MH, Winkelman JW, Högl B, Bainbridge J, Buchfuhrer M, Hadjigeorgiou G, Inoue Y, Manconi M, Oertel W, Ondo W, Winkelmann J, Allen RP. Guidelines for the first-line treatment of restless legs syndrome/Willis-Ekbom disease, prevention and treatment of dopaminergic augmentation: a combined task force of the IRLSSG, EURLSSG, and the RLS-foundation. Sleep Med. 2016 May;21:1-11. doi: 10.1016/j.sleep.2016.01.017. Epub 2016 Feb 23. PMID: 27448465.

Case Reports

01

Wang XX, Feng Y, Tan EK, Ondo WG, Wu YC. Stroke-related restless legs syndrome: epidemiology, clinical characteristics, and pathophysiology. Sleep Med. 2022 Feb;90:238-248. doi: 10.1016/j.sleep.2022.02.001. Epub 2022 Feb 9. PMID: 35219214.

02

Winkelman JW, Grant NR, Molay F, Stephen CD, Sadjadi R, Eichler FS. Restless Legs Syndrome in X-linked adrenoleukodystrophy. Sleep Med. 2022 Mar;91:31-34. doi: 10.1016/j.sleep.2022.02.008. Epub 2022 Feb 16. PMID: 35245789; PMCID: PMC9035065.

The IRLSSG is committed to the principles of open and full scientific communication and collaboration, peer review, full disclosure of potential conflicts of interest, and democratic governance of its organization and activities.

Useful Links

Get In Touch

Administrative Office
3270 19th St NW, Suite 110,
Rochester, MN 55901 USA
Phone: +1.507.316.0084

Join our email list

Copyright © 2025 . All rights reserved.